At a university, you have to accept that people are going to do stuff
One of the things that you have to accept as a university system administrator is that people are going to do stuff, whether you like it or not. In a corporation, perhaps you can build a system that works like a maze, with carefully charted and fenced-in footpaths that people stick to. In a university, what you get in practice is more like a field with a certain amount of desire paths in it. You can build paths and exhort people to not step on the grass, but they're going to do it anyway. And obviously, the more pathways you don't build, the more people are going to make their own paths.
(I suspect that many corporate environments are more like fields with desire paths than the people operating them realize or at least admit to. Most people's priority is getting their job done, regardless of what that takes.)
I used the analogy of desire paths deliberately. As university sysadmins, what people do on the department's systems tells us both what they want (or at least think is the natural thing to do) and what they think is the easiest or best way to get it. If people are perpetually running big programs on our main login server or our SLURM head node, this tells us something. We could try setting (very) small resource limits (with possible side effects) and possibly try to nag people who still load the machine down, or we can get a very big primary login server and let people use effectively a decent desktop's worth of its resources (and make it possible to submit SLURM jobs from our general purpose compute servers). Having been through both options, I can tell you which one works much better (the second, although we probably don't need a login server that's quite as big as our current one). The reason it worked better was that we were paving the desire path people showed us, rather than trying to tell people not to walk down their desire path.
(The SLURM job submission example shows that it is possible to change people's behavior over time if you give them a better way and then patiently keep leading them to it. But to be honest it took a while.)
One part of this today is that some of what people do is going to strike you or at least your security people as not merely wrong but dangerous (or bad, at least). In a university environment there may not be much you can do about this, at least in practice. You can write policies and then try to enforce them either through generally limited technical means or often-challenging alternate methods on people who aren't employees, but I don't think this is going to work well. When people do security-alarming things on your systems, they're showing you their desire paths. Trying to insist that people not walk on the grass or fencing off bits of it is probably going to go about as well as it ever does.
(This is an aspect of why people-hostile policies are a mistake.)
Reminding myself about this helps me cultivate a relaxed, philosophical attitude about what I casually notice people doing on our systems (through process listings, our metrics system, or whatever). People are going to do stuff on the department's systems and some of that stuff is going to make me wish they weren't doing it, and that's life. Getting worked up about it and trying to do something would turn me into a certain sort of excessively controlling and authoritarian system administrator, which wouldn't be good for either me or the people here.
(You don't want to become that sort of system administrator, in part because people will consider you damage and route around you. Or to put it another way, if you always say 'no' people will stop talking to you at all.)