US sanctions and your VPN (and certain big US-based cloud providers)
As you may have heard (also) and to simplify, the US government requires US-based organizations to not 'do business with' certain countries and regions (what this means in practice depends in part which lawyer you ask, or more to the point, that the US-based organization asked). As a Canadian university, we have people from various places around the world, including sanctioned areas, and sometimes they go back home. Also, we have a VPN, and sometimes when people go back home, they use our VPN for various reasons (including that they're continuing to do various academic work while they're back at home). Like many VPNs, ours normally routes all of your traffic out of our VPN public exit IPs (because people want this, for good reasons).
Getting around geographical restrictions by using a VPN is a time honored Internet tradition. As a result of it being a time honored Internet tradition, a certain large cloud provider with a lot of expertise in browsers doesn't just determine what your country is based on your public IP; instead, as far as we can tell, it will try to sniff all sorts of attributes of your browser and your behavior and so on to tell if you're actually located in a sanctioned place despite what your public IP is. If this large cloud provider decides that you (the person operating through the VPN) actually are in a sanctioned region, it then seems to mark your VPN's public exit IP as 'actually this is in a sanctioned area' and apply the result to other people who are also working through the VPN.
(Well, I simplify. In real life the public IP involved may only be one part of a signature that causes the large cloud provider to decide that a particular connection or request is from a sanctioned area.)
Based on what we observed, this large cloud provider appears to deal with connections and HTTP requests from sanctioned regions by refusing to talk to you. Naturally this includes refusing to talk to your VPN's public exit IP when it has decided that your VPN's IP is really in a sanctioned country. When this sequence of events happened to us, this behavior provided us an interesting and exciting opportunity to discover how many companies hosted some part of their (web) infrastructure and assets (static or otherwise) on the large cloud provider, and also how hard to diagnose the resulting failures were. Some pages didn't load at all; some pages loaded only partially, or had stuff that was supposed to work but didn't (because fetching JavaScript had failed); with some places you could load their main landing page (on one website) but then not move to the pages (on another website at a subdomain) that you needed to use to get things done.
The partial good news (for us) was that this large cloud provider would reconsider its view of where your VPN's public exit IP 'was' after a day or two, at which point everything would go back to working for a while. This was also sort of the bad news, because it made figuring out what was going on somewhat more complicated and hit or miss.
If this is relevant to your work and your VPNs, all I can suggest is to get people to use different VPNs with different public exit IPs depending on where the are (or force them to, if you have some mechanism for that).
PS: This can presumably also happen if some of your people are merely traveling to and in the sanctioned region, either for work (including attending academic conferences) or for a vacation (or both).
(This is a sysadmin war story from a couple of years ago, but I have no reason to believe the situation is any different today. We learned some troubleshooting lessons from it.)